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Nobel Prize winner for revolutionary 'knockout mouse' gene-targeting research technique speaks Sept. 22

September 19, 2010

Mario R. Capecchi, 2007 Nobel Prize Winner in Physiology or Medicine, will be presenting a seminar on Wednesday, Sept. 22 at 4 p.m. in Room 131, Behavioral Sciences Building titled, "Gene Targeting into the 21st Century: Mouse Models of Human Disease from Cancer to Neuropsychiatric Disorders."

"Gene Targeting into the 21st Century"
Mario R. Capecchi
Wednesday, Sept. 22
4-5 p.m.
Behavioral Sciences Building, Room 131

Mario R. Capecchi (right), Distinguished Professor of Human Genetics and Biology at the University of Utah Eccles Institute of Human Genetics and a Howard Hughes Medical Institute Investigator, is best known for his pioneering work on the development of gene targeting in mouse embryo-derived stem (ES) cells. This technology allows scientists to create mice with mutations in any desired gene.

Function of genes during development

The power of this technology is that the investigator chooses both which gene to mutate and how to mutate it. The investigator has virtually complete freedom on how to manipulate the DNA sequences in the genome of living mice. This allows scientists to evaluate in detail the function of any gene during the development or post-developmental phase of the mouse.

Capecchi's research interests include:

  • The molecular genetic analysis of early mouse development
  • Neural development in mammals
  • Production of murine models of human genetic diseases
  • Gene therapy
  • Homologous recombination and programmed genomic rearrangements in the mouse

The seminar is in conjunction with the Frontiers in Biomedical Sciences Seminar Series, the Molecular, Cellular and Integrative Neurosciences program, and the Cell and Molecular Biology program.

Refreshments will follow the talk.

Contact: Lora.Sonday
Phone: (970) 491-7203